This study was carried out to measure the concentrations of heavy metals of Lead and Zinc in muscle tissues of two species of (Scomberomorus commerson) and (Scomberomorus guttatus) in Bushehr seaport during summer 2015. 20 samples of Scomberomorus commerson and 20 samples of Scomberomorus guttatus were caught randomly from Bushehr seaport by using a gillnet. After biometry of the samples, the muscle tissues were separated and chemical digestion was done, then Lead and Zinc accumulation levels in muscles were measured using Graphite furnace atomic absorption instrument. Based on the obtained results the mean concentrations of Lead in muscle tissues of Scomberomorus commerson and Scomberomorus guttatus were calculated 0.349 ± 0.173 and 0.384 ± 0.132 mg/kg dry weight respectively and showed that there were no significant differences (P>0.05). Moreover, based on the obtained results the mean concentrations of Zinc in muscle tissues of Scomberomorus commerson and Scomberomorus guttatus were calculated 35.1 ± 11.855 and 40.8 ± 11.988 mg/kg dry weight respectively and showed that there were no significant differences (P>0.05). The results of this study revealed that the Lead metal concentration in muscle tissues of Scomberomorus commerson and Scomberomorus guttatus are lower than the levels permitted within the standards of World Health Organization (WHO), Food and Agricultural Organization (FAO), National Health and Medical Research Council (Australia) (NHMRC) and Ministry of Agriculture, Forestry and Fisheries (MAFF) but the Zinc metal concentration in muscle tissues of Scomberomorus commerson and Scomberomorus guttatus are higher than the levels permitted within the standards of Food and Agricultural Organization (FAO), and lower than the levels permitted within the standards of World Health Organization (WHO), National Health and Medical Research Council (Australia) (NHMRC) and Ministry of Agriculture, Forestry and Fisheries (MAFF). Therefore, additional researches are needed to evaluate any potential effluence of this fish consumption on human health.